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E' commercializzato in Italia dall'azienda Sanofi S. Titolare: Sanofi S. Concessionario: Sanofi S. Ricetta: RR - medicinali soggetti a prescrizione medica Classe: A Principio attivo: Idrossiclorochina Solfato Gruppo terapeutico: Antimalarici, clorochina Forma farmaceutica: compressa rivestita. È indicato per il trattamento dell'artrite idiopatica giovanile in terapia d'associazione , e per il lupus sistemico eritematoso e discoide.
Artrite reumatoide : il farmaco agisce per accumulo e sono necessarie alcune settimane perchè si manifestino i primi effetti benefici, mentre lievi disturbi possono presentarsi relativamente presto. Possono essere necessari diversi mesi di cura prima che si possano ottenere gli effetti massimi. Se un miglioramento obiettivo non si rileva entro sei mesi è opportuno sospendere il trattamento.
Dosaggio iniziale : da a mg al giorno da 2 a 3 compresse rivestite somministrati ai pasti o con un bicchiere di latte. Dose di mantenimento : quando si ottiene una buona risposta terapeutica, di solito tra le 4 e le 12 settimane, la dose viene ridotta a metà, da a mg 1 o 2 compresse rivestite al giorno.
È stata descritta una più alta incidenza di retinopatia qualora si superi questa dose. I corticosteroidi ed i salicilati possono essere usati di solito a dosi ridotte in associazione a PLAQUENIL o possono essere del tutto sospesi dopo che il farmaco è stato somministrato per parecchie settimane. Lupus eritematoso : la dose media iniziale è di mg una o due volte al giorno.
Per una terapia di mantenimento spesso basterà una dose più bassa da a mg al giorno.
È stata descritta una più alta incidenza di retinopatia quando si supera questa dose di mantenimento. Popolazione pediatrica: deve essere impiegata la dose minima efficace e non bisogna mai eccedere la dose di 6. Yorum İsim E-posta İnternet sitesi.
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